MR parkinsonism index predicts vertical supranuclear gaze palsy in patients with PSP–parkinsonism

نویسندگان

  • Aldo Quattrone
  • Maurizio Morelli
  • David R. Williams
  • Basilio Vescio
  • Gennarina Arabia
  • Salvatore Nigro
  • Giuseppe Nicoletti
  • Maria Salsone
  • Fabiana Novellino
  • Rita Nisticò
  • Franco Pucci
  • Carmelina Chiriaco
  • Pierfrancesco Pugliese
  • Domenico Bosco
  • Manuela Caracciolo
چکیده

OBJECTIVE To identify a biomarker for predicting the appearance of vertical supranuclear gaze palsy (VSGP) in patients affected by progressive supranuclear palsy-parkinsonism (PSP-P). METHODS Twenty-four patients with PSP-P were enrolled in the current study. Patients were clinically followed up every 6 months until the appearance of VSGP or the end of the follow-up (4 years). Participants underwent MRI at baseline and at the end of follow-up. Magnetic resonance parkinsonism index (MRPI), an imaging measure useful for diagnosing PSP, was calculated. RESULTS Twenty-one patients with PSP-P completed follow-up, and 3 patients dropped out. Eleven of 21 patients with PSP-P developed VSGP after a mean follow-up period of 28.5 months (range 6-48 months), while the remaining 10 patients with PSP-P did not develop VSGP during the 4-year follow-up period. At baseline, patients with PSP-P who later developed VSGP had MRPI values significantly higher than those of patients not developing VSGP without overlapping values between the 2 groups. MRPI showed a higher accuracy (100%) in predicting VSGP than vertical ocular slowness (accuracy 33.3%) or postural instability with or without vertical ocular slowness (accuracy 71.4% and 42.9%, respectively). CONCLUSIONS Our study demonstrates that MRPI accurately predicted, on an individual basis, the appearance of VSGP in patients with PSP-P, thus confirming clinical diagnosis in vivo.

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عنوان ژورنال:

دوره 87  شماره 

صفحات  -

تاریخ انتشار 2016